Lipolysis

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Lipolysis

Successful adaptation to starvation in mammals depends heavily on the regulated mobilization of fatty acids from triacylglycerols stored in adipose tissue. Although it has long been recognized that cyclic AMP represents the critical second messenger and hormone-sensitive lipase (HSL)**Abbreviations used in this paper: ADRP, adipocyte differentiation-related protein; HSL, hormone-sensitive lipas...

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Molecular adaptations of lipolysis to physical activity

The purpose of the present study was to investigate the context of lipid metabolism research in physical activity, lipolysis, lipolysis hormone regulation and the fate of lipolysis products in exercise, fatty acid transporters, some genes involved in lipid metabolism, effect of resistance activity on lipolysis, adaptations of adipose tissue due to physical activity, lipoproteins and apoproteins...

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Lipolysis during Fasting

These studies were designed to determine whether the insulin resistance of fasting extends to its antilipolytic effects and whether fasting enhances the lipolytic effects ofadrenergic stimulation independent ofchanges in plasma hormone and substrate concentrations. Palmitate flux was determined isotopically (il-'4Cjpalmitate) before and during epinephrine infusion in normal volunteers after a 1...

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Regulation of adipocyte lipolysis.

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation are the best known. Initially, hormone-sensit...

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Growth and lipolysis

The purpose of the present work was to study ageand weight-controlled rats to determine which is the primary factor in reducing the lipolytic response of free fat cells and which has the greater effect on the ratio of fat cells to nonfat cells in adipose tissue. The method for estimating fa t cell and nonfat cell numbers is based on the analysis of adipose tissue and fat cell DNA and lipid. In ...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2003

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.200306008